A Prospective Study to Evaluate Clinical Outcomes in Patients With Anti-leucine-rich Glioma-inactivated 1 Encephalitis

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

Anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis has been increasingly identified as the second most common type of autoimmune encephalitis after anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. It presents with acute or subacute onset of epileptic seizures, anterograde amnesia, behavior disturbances, sleep disorders and hyponatremia. In most patients with anti-LGI1 encephalitis, immunotherapy is successful in treating the encephalitis. However, relapses, chronic epilepsy, cognitive declines and psychiatric problems have been reported in some cases. So far, prospective studies to evaluate its clinical outcomes still remain limited. In this project, the investigators will use clinical features and advanced paraclinical examinations to prospectively investigate the clinical outcomes and the associated factors in patients with anti-LGI1 encephalitis.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 100
Healthy Volunteers: f
View:

• Meet the 2016 consensus diagnostic criteria for anti-LGI1 encephalitis.

• Newly diagnosed, and during the acute stage before study enrollment.

• Sign the informed consent form.

Locations
Other Locations
China
2nd Affiliated Hospital, School of Medicine, Zhejiang University, China
RECRUITING
Hangzhou
Contact Information
Primary
Mei-Ping Ding
dmp-neurology@zju.edu.cn
+86 0571 87783872
Time Frame
Start Date: 2022-05-18
Estimated Completion Date: 2032-12-31
Participants
Target number of participants: 60
Sponsors
Leads: Shen Chun-Hong

This content was sourced from clinicaltrials.gov