Overview
Nicholas Maragakis treats patients with motor neuron diseases, such as amyotrophic lateral sclerosis (ALS). This care is coordinated with the Johns Hopkins Center for ALS Specialty Care, a multidisciplinary clinic with expertise in treating patients with ALS and providing support to their caregivers. He serves as medical director of the ALS Clinical Trials Unit, an extension of the multidisciplinary clinic that seeks to facilitate opportunities for patients with ALS to participate in clinical trials that could advance the treatment of this disease. Dr. Maragakis is interested in the basic science of understanding neurodegenerative diseases, as well as the translational potential of therapeutic compounds developed in the laboratory. His fundamental research interest is in using stem cells — more specifically, stem cell-derived motor neurons and glia — for understanding the development and propagation of ALS. His laboratory has been involved in creating and characterizing lines of stem cells from patients with ALS using induced pluripotent stem cell (iPSC) methodologies. The laboratory has a large library of iPSCs from patients with familial ALS and from patients with sporadic ALS. The utilization of this library of iPSCs has facilitated the development of a spinal cord-specific iPSC-astrocyte/motor neuron co-culture system, which has been leveraged for the development of assays that can be used for both the basic understanding of ALS astrocyte and motor neuron biology as well as, eventually, drug screening for ALS therapeutics. His laboratory has taken its long-standing interests in astrocyte biology, as it relates to ALS, to develop a program that investigates astrocyte-specific mechanisms as contributors to the progression (both temporally and anatomically) of disease in ALS. In this vein, there is an interest in astrocytic glutamate transporters and, more recently, astrocyte hemichannels and gap junctions.
Dr. Maragakis is rated as an Experienced provider by MediFind in the treatment of Paraplegia. His top areas of expertise are Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease), Primary Lateral Sclerosis, 15q11.2 Microdeletion, and Spinal Muscular Atrophy (SMA).
His clinical research consists of co-authoring 115 peer reviewed articles and participating in 3 clinical trials. MediFind looks at clinical research from the past 15 years. In particular, he has co-authored 1 article in the study of Paraplegia.
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Locations
601 North Caroline Street, Floor 5, Floor 5, Baltimore, MD 21287
Clinical Research
Clinical research consists of overseeing clinical studies of patients undergoing new treatments and therapies, and publishing articles in peer reviewed medical journals. Providers who actively participate in clinical research are generally at the forefront of the fields and aware of the most up-to-date advances in treatments for their patients.
3 Clinical Trials
Johns Hopkins Outpatient Center
Dr. Ricardo Roda earned a combined MD/PhD degree from University of Rochester and completed an adult neurology residency, followed by a clinical neuromuscular fellowship at Johns Hopkins University School of Medicine. During residency, Dr. Roda developed a special interest in both auto-immune disorders and genetic disorders. Following residency, he spent three years in neurogenetics branch of National Institute of Neurological Disorders and Stroke (NINDS) working with Dr. Craig Blackstone, focusing on the use of the newer DNA sequencing techniques in genetic diagnosis, and in establishing genotype/phenotype correlations neuromuscular disorders. His current clinical interests include developing testing strategies for undiagnosed genetic disorders and myasthenia gravis. Dr. Roda is rated as a Distinguished provider by MediFind in the treatment of Paraplegia. His top areas of expertise are Spastic Paraplegia Type 7, Hereditary Spastic Paraparesis, Myasthenia Gravis, and Spastic Paraplegia Type 2.
Johns Hopkins Outpatient Center
Neurologist Payam Mohassel specializes in myopathies, muscular dystrophies, and other hereditary neuromuscular disorders and is the co-director of the Johns Hopkins Myositis Center. Dr. Mohassel obtained his medical degree from the Johns Hopkins University School of Medicine, where he remained for a medical internship, residency training in neurology, and clinical fellowship training in neuromuscular medicine. He then joined the National Institute of Neurological Disorders and Stroke Neurogenetics branch as a clinical research fellow. Dr. Mohassel’s research focuses on translational studies on neuromuscular disorders, and it spans gene discovery efforts, mechanistic studies to identify therapeutic targets, and early phase interventional clinical trials. Dr. Mohassel is rated as an Advanced provider by MediFind in the treatment of Paraplegia. His top areas of expertise are Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease), Primary Lateral Sclerosis, Hereditary Sensory Neuropathy Type 1 (HSN1), and Hereditary Sensory and Autonomic Neuropathy Type 2.
Comprehensive Neurology Services, PA
Sean Burke is a Neurologist and a Neuromusculoskeletal Medicine provider in Frederick, Maryland. Dr. Burke is rated as an Advanced provider by MediFind in the treatment of Paraplegia. His top areas of expertise are Seizures, Multiple Sclerosis (MS), Relapsing Multiple Sclerosis (RMS), and Peripheral Neuropathy. Dr. Burke is currently accepting new patients.
Areas of Expertise
MediFind evaluates expertise by pulling from factors such as number of articles a doctor has published in medical journals, participation in clinical trials, speaking at industry conferences, prescribing and referral patterns, and strength of connections with other experts in their field.
Learn more about MediFind’s expert tiers
- Elite
- 15q11.2 MicrodeletionDr. Maragakis isElite. Learn about 15q11.2 Microdeletion.
- Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease)
- Primary Lateral SclerosisDr. Maragakis isElite. Learn about Primary Lateral Sclerosis.
- Distinguished
- DysarthriaDr. Maragakis isDistinguished. Learn about Dysarthria.
- Spinal and Bulbar Muscular AtrophyDr. Maragakis isDistinguished. Learn about Spinal and Bulbar Muscular Atrophy.
- Spinal Muscular Atrophy (SMA)Dr. Maragakis isDistinguished. Learn about Spinal Muscular Atrophy (SMA).
- Spinal Muscular Atrophy Type 3Dr. Maragakis isDistinguished. Learn about Spinal Muscular Atrophy Type 3.
- Experienced
- Alternating Hemiplegia of ChildhoodDr. Maragakis isExperienced. Learn about Alternating Hemiplegia of Childhood.
- Chronic PolyradiculoneuritisDr. Maragakis isExperienced. Learn about Chronic Polyradiculoneuritis.
- Cramp-Fasciculation SyndromeDr. Maragakis isExperienced. Learn about Cramp-Fasciculation Syndrome.
- Creutzfeldt-Jakob DiseaseDr. Maragakis isExperienced. Learn about Creutzfeldt-Jakob Disease.
- DementiaDr. Maragakis isExperienced. Learn about Dementia.
- Dry MouthDr. Maragakis isExperienced. Learn about Dry Mouth.