Impairments of Neuro-muscular Communication in Motor-Neuron Disease: A Bio-Marker for Early and Personalised Diagnosis

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Observational
SUMMARY

Motor neuron disease (MND) or ALS is a nervous system disease. ALS leads to a loss of movement ability that eventually leads to death. At the moment, there is no known treatment for ALS. Early diagnosis in individuals improves clinical care and facilitates timely entry into clinical trials. However, current methods for diagnosis are primarily clinical, and to date, no cost-effective biomarkers have been developed. Our objective is to identify a robust non-invasive neurophysiological-based system that can be used both as a biomarker of disease onset, and a measurement of progression using quantitative EEG and surface EMG (bipolar and high-density). The investigators postulate that analysing the joint recordings of EEG and EMG (bipolar or high-density) can give measures that better distinguish healthy people and ALS patient subgroups and that the findings can be developed as biomarkers of early diagnosis and disease progression.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

⁃ Healthy Volunteers:

• age and gender-matched to patient groups

• the intact physical ability to take part in the experiment.

⁃ Patients:

• Diagnosis of ALS, PLS, PMA, SMA, Polio or MS

• capable of providing informed consent.

Locations
Other Locations
Ireland
Academic Unit of Neurology, Trinity College Dublin, The University of Dublin
RECRUITING
Dublin
Contact Information
Primary
Orla Hardiman, BSc MB BCh BAO MD FRCPI FAAN
hardimao@tcd.ie
+353 1 896 4497
Backup
Saroj Bista, MSc
sbista@tcd.ie
+353 89 945 8246
Time Frame
Start Date: 2015-10-01
Estimated Completion Date: 2027-09-30
Participants
Target number of participants: 400
Treatments
Controls
Individuals from the Irish population with no psychiatric, psychological, neurological or muscular disease diagnosis.
Amyotrophic lateral sclerosis patients
Individuals from the Irish population (Irish Motorneuron Disease Register) with possible/probable/definitive diagnosis of ALS.
Postpoliomyelitis syndrome
Individuals from the Irish population (Irish Motorneuron Disease Register) with postpoliomyelitis syndrome diagnosis.
Spinal Muscular Atrophy
Individuals from the Irish population (Irish Motorneuron Disease Register) with spinal muscular atrophy diagnosis.
Sponsors
Collaborators: Research Motor Neuron, IE, Irish Research Council, IE, Motor Neurone Disease Association, UK, Thierry Latran Foundation, FR, ALS Association, USA
Leads: University of Dublin, Trinity College

This content was sourced from clinicaltrials.gov

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