Dr. Chengcheng Gui

Dr. Chengcheng Gui is an instructor in the Department of Radiation Oncology and Molecular Radiation Sciences at the Johns Hopkins University School of Medicine. His clinical focus is the use of radiotherapy to treat head and neck cancers, as well as skin cancers. Dr. Gui obtained his medical degree from the Johns Hopkins University School of Medicine and completed his residency training at Memorial Sloan Kettering Cancer Center, where he served as chief resident and received the Radiation Oncology Medical Student Teaching Award. Dr. Gui believes that cancer patients deserve a clear and thorough understanding of the benefits and risks of their treatment options, empowering them to choose the path that best aligns with their personal values. To support this, Dr. Gui is committed to being an approachable, trustworthy source of information, while also planning and delivering high-quality radiotherapy. Research Summary Dr. Gui's research focuses on enhancing the safety and effectiveness of radiotherapy by integrating multiple data modalities. His work incorporates advanced structural and functional imaging, tumor molecular characteristics, and patient-reported outcomes to inform and personalize treatment approaches. Selected Publications Gui C, Wray R, Schöder H, Deasy JO, Grkovski M, Humm JL, Wong RJ, Sherman EJ, Riaz N, Lee NY. Tumor hypoxia on 18F-fluoromisonidazole positron emission tomography and distant metastasis from head and neck squamous cell carcinoma. JAMA Network Open. 2024 Sep 3;7(9):e2436407-. Gui C, Walch H, Mueller K, Boe L, Skakodub A, Miao E, Khatri I, Kumar R, Padilla Mazzeo, Shen J, Cooper C, Parker M, Hsu A, Patel R, Ilica AT, Stember JN, Eichholz JE, Bou Nassif R, Yu KKH, Wilcox JA, Manca P, Yu Y, Yamada Y, Imber BS, Maron SB, Foote MB, Chatila WK, Yaeger R, Schultz N, Pike LRG. Genomics correlates of brain metastasis and progression in colorectal cancer. Neuro-Oncology. 2025 Aug 28:noaf198. doi: 10.1093/neuonc/noaf198. Online ahead of print. Gui C, Vannorsdall TD, Kleinberg LR, Assadi R, Moore JA, Hu C, Quiñones-Hinojosa A, Redmond KJ. A prospective cohort study of neural progenitor cell-sparing radiation therapy plus temozolomide for newly diagnosed patients with glioblastoma. Neurosurgery. 2020 Jul 1;87(1):E31-40. Redmond KJ, Gui C, Benedict S, Milano MT, Grimm J, Vargo JA, Soltys SG, Yorke E, Jackson A, El Naqa I, Marks LB. Tumor control probability of radiosurgery and fractionated stereotactic radiosurgery for brain metastases. International Journal of Radiation Oncology* Biology* Physics. 2021 May 1;110(1):53-67. Eitz KA, Lo SS, Soliman H, Sahgal A, Theriault A, Pinkham MB, Foote MC, Song AJ, Shi W, Redmond KJ, Gui C, Kumar AMS, Machtay M, Meyer B, Combs SE. Multi-institutional analysis of prognostic factors and outcomes after hypofractionated stereotactic radiotherapy to the resection cavity in patients with brain metastases. JAMA Oncology. 2020 Dec 1;6(12):1901-9.

Dr. Gui is rated as an Experienced provider by MediFind in the treatment of Primary Lymphoma of the Brain. His top areas of expertise are Brain Tumor, Primary Lymphoma of the Brain, Myxoid Liposarcoma, Endoscopy, and Osteotomy.

His clinical research consists of co-authoring 46 peer reviewed articles. MediFind looks at clinical research from the past 15 years. In particular, he has co-authored 1 article in the study of Primary Lymphoma of the Brain.