Changes in Antibacterial Therapy Based on Perioperative Dynamics of Presepsin During Reconstructive Thoracic Aorta Surgery
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
According to the literature, presepsin was recommended not only as an effective indicator in the diagnosis of sepsis in intensive care units, but also as a reliable prognostic marker of postoperative inflammatory processes in cardiac surgery. Previous study carried out in Petrovsky NRCS related to biomarkers in cardiac surgery and presepsin in particular showed good sensitivity in infection complications prognosis.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:
• Thoracic aorta aneurysm/dissection
Locations
Other Locations
Russian Federation
Petrovsky Research National Centre of Surgery (Petrovsky NRCS)
RECRUITING
Moscow
Contact Information
Primary
Artem Gubko, Ph.D.
gubko@artvig.ru
+79684241490
Backup
Boris Akselrod, Professor
aksel@mail.ru
+79257403797
Time Frame
Start Date: 2024-02-19
Estimated Completion Date: 2025-12-15
Participants
Target number of participants: 50
Treatments
Experimental: Ampicillin/sulbactam intervention group
If a patient meets dual criteria (presepsin \> 519,5 pg/ml at the end of surgery and the absence of presepsin increase after 6 hours after the end of surgery) then switching to ampicillin/sulbactam 3 g every 6 hours at least 72 h after the surgery is done.
No_intervention: Cefazolin
If presepsin \< 519,5 pg/ml at the end of surgery, cefazolin 2 g every 6 h at least 72 h p/o is continued further
Related Therapeutic Areas
Sponsors
Leads: Petrovsky National Research Centre of Surgery