⁃ All participants (adults, children, infants at 9 months of age and infants at 6 weeks of age) will be enrolled in the clinical site in Ghana and must satisfy ALL the following criteria at study entry:

• Participants and/or participants' parent(s)/Legally Acceptable Representative(s) (LAR), who, in the opinion of the investigator, can and will comply with the requirements of the protocol (e.g., completion of the diary cards, return for follow-up visits).

• Written or witnessed/thumb printed informed consent obtained from the participant/parent(s)/LAR(s) of the participant prior to performance of any study-specific procedure.

• Healthy participants as established by medical history, clinical examination, and laboratory investigations.

• Participants satisfying screening requirements.

• Participants negative for human immunodeficiency virus (HIV), hepatitis B, and hepatitis C.

⁃ Adult participants must satisfy ALL the following criteria at study entry:

• A male or female between and including 18 and 50 years of age at the time of the first study intervention administration.

• Female participants of non-childbearing potential may be enrolled in the study. Non-childbearing potential is defined as pre-menarche, current bilateral tubal ligation or occlusion, hysterectomy, bilateral ovariectomy or post-menopause.

• Female participants of childbearing potential may be enrolled in the study if the participant:

⁃ has practiced adequate contraception for 1 month prior to study intervention administration, and:

• has a negative pregnancy test on the day of study intervention administration, and

• has agreed to continue adequate contraception during the entire treatment period and for 1 month after completion of the study intervention administration series.

⁃ The Ghana card will be used as source document to verify the ages for the adults.

⁃ Child participants must satisfy ALL the following criteria at study entry:

• A male or female between and including 24 and 59 months of age at the time of the first study intervention administration.

• Previously completed routine childhood vaccinations to the best knowledge of the participant's parent(s)/LAR's.

• Born after a gestation period of ≥37 weeks.

⁃ Infant participants must satisfy ALL the following criteria at study entry:

• A male or female 6 weeks or 9 months of age at the time of the first study intervention administration.

• Born after a gestation period of ≥37 weeks.

• Born to a mother seronegative for HIV, hepatitis B virus and hepatitis C virus.

⁃ The Road to Health Chart will be used as source document to confirm the ages for the children and infants.