Clinical trials related to Deep Brain Stimulation Procedure
Neurophysiology of the Basal Ganglia, Thalamus, and Cerebellum in Patients With Movement Disorders
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The research study is being conducted to better understand parts of the human brain called the cortex, basal ganglia, thalamus, and cerebellum in patients with movement disorders (such as Parkinson's disease, essential tremor, dystonia, or ataxia). These brain structures are involved in movement disorders. This study attempts to better understand the brain electrical activity associated with these disorders, both in patients with and without deep brain stimulation (DBS). Recordings are made from the scalp with a noninvasive electrode and/or through the DBS stimulator if the participant has a stimulator model that is able to sense brain activity. These recordings are analyzed along with measures of movement disorder symptoms to identify brain signal signatures of symptoms.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Patients 18 years of age and above
• Any patient who has been diagnosed by a movement disorders neurologist with one of the following movement disorders:
• Parkinson's disease
• Dystonia
• Tremor, including essential tremor
• Cerebellar ataxia
• Other hyperkinetic movement disorders, such as chorea and tics
Locations
United States
Pennsylvania
Pennsylvania Hospital
RECRUITING
Philadelphia
Time Frame
Start Date:2025-12-10
Estimated Completion Date:2030-04
Participants
Target number of participants:100
Treatments
Experimental: Participants without Deep Brain Stimulators
Multimodal neurophysiology (for example, electroencephalography and electromyography) will be measured during the following:~Movement disorder medication administration -The patient's movement disorders medications, prescribed by their treating physicians outside of this study, may be administered during an experimental session.
Experimental: Participants with Deep Brain Stimulators
Multimodal neurophysiology (for example, electroencephalography and electromyography) will be measured during the following:~Movement disorder medication administration -The patient's movement disorders medications, prescribed by their treating physicians outside of this study, may be administered during an experimental session.~Deep brain stimulator (DBS) adjustment - Participants who have had deep brain stimulation implantation as part of their standard-of-care clinical treatment may participate in this study. The patient's stimulator may be adjusted within normal clinical limits during an experimental session.