Comparison of Imaging Quality Between Spectral Photon Counting Computed Tomography (SPCCT) and Dual Energy Computed Tomography (DECT)

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This pilot study wants to determine to which extent SPCCT allows obtaining images with improved quality and diagnostic confidence when compared to standard Dual Energy CT (DECT), both with and without contrast agent injection. Depending on the anatomical structures/organs to be visualized during CT examinations, different scanning protocols are performed with quite variable ionizing radiation doses. Therefore, in order to obtain the most extensive and representative results of the improvement in image quality between SPCCT and DECT that will be performed CT imaging on several body regions and structures, including diabetic foot, diabetic calcium coronary scoring, adrenal glands, coronary arteries, lung parenchyma, kidney stones, inner ear, brain and joints, earl/temporal bone, colorectal carcinosis.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patients presenting following one of following medical conditions:

‣ Asymptomatic type 1 or 2 diabetes as regard to cardiovascular risks

⁃ Diabetic foot ulcer

⁃ Adrenal glands lesions: Adrenal incidentaloma or hyperaldosteronism or macroadenoma

⁃ Urinary stone(s)

⁃ Known Coronary artery disease: Stent imaging or control of calcified plaques

⁃ Diffuse Interstitial Lung Diseases: Idiopathic Pulmonary Fibrosis, Hypersensitivity Pneumonitis, Ground Glass Opacification, Chronic Thromboembolic Pulmonary Hypertension

⁃ Conductive hearing loss

⁃ Brain stroke (late or post thrombectomy)

⁃ Intracranial arteriovenous malformation treated with coils or Onyx

‣ Joints diseases in haemophilia

‣ Ear/temporal bone

‣ Colorectal carcinosis

‣ Dissection aortique de type A opérée ou de type B non opérée, hématome intramural

• Patient has accepted to participate to the study and has signed the written consent;

• Pre-menopausal women only: Negative urinary pregnancy test on the day of imaging before the administration of study drug;

• Patient is affiliated to the French social security

Locations
Other Locations
France
Hôpital Cardiologique Louis Pradel - Hospices Civils de Lyon
RECRUITING
Bron
Contact Information
Primary
Philippe DOUEK, Pr
douek@creatis.insa-lyon.fr
04 72 07 18 83
Backup
Adeline MANSUY
adeline.mansuy@chu-lyon.fr
04 72 11 51 70
Time Frame
Start Date: 2021-01-29
Estimated Completion Date: 2026-01-29
Participants
Target number of participants: 339
Treatments
Experimental: SPCCT and standard DECT
Comparative intra-patients (each patient will have both types of scanner imaging done), clinical superiority study, evaluating the imaging performances (e.g. image quality and radiation dose) of SPCCT and standard DECT for several body regions/anatomical structures.
Sponsors
Leads: Hospices Civils de Lyon

This content was sourced from clinicaltrials.gov