Brain Mechanisms Supporting Cannabis-induced Pain Relief
Chronic low back pain is a common and disabling condition that affects millions of people in the United States. Many people with chronic low back pain do not get enough relief from current treatments. Cannabis may help reduce pain, but researchers do not fully understand how it affects the brain in people with chronic pain. The purpose of this study is to examine how inhaled cannabis changes brain activity and reduces pain in people with chronic low back pain. Results from this study may help researchers better understand how cannabis works for pain and support the development of improved pain treatments.
• Between 21-65 years old
• Currently 30 days cannabis free
• Lower back pain for three months or more
• Are not taking opioids
• If female and of a child bearing potential age, are not pregnant or nursing mothers
• Do not have mental or neurological conditions inhibiting sensory/motor functions
• Do not have a lifetime history of dependence on cannabis
• Do not have a lifetime history of DSM-IV schizophrenia, bipolar disorder, panic disorder, or psychosis
• Prior THC-containing cannabis experience within the past two years
• Agrees not to use cannabis outside of the study during participation in the study
• Agrees not to use opioids or barbiturates during participation in the study
• Agrees not to drive a motor vehicle within 4 hours following last use of inhaled cannabis during participation in the study