Description of Septic Thrombophlebitis on Central Venous Catheter and Midline

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Central venous catheters improve the tolerability and feasibility of patient care in the hospital setting by allowing the administration of hyper-osmotic, vesicant and venotoxic fluids. Despite these advantages, the long-term presence of central venous catheters is associated with thrombotic and infectious risks , including catheter-related bacteremia, which can be complicated by septic thrombophlebitis and endocarditis that can lead to death. Septic thrombophlebitis is a complication of venous catheter infections, which increases the morbidity. It is defined by the presence of a thrombosis in the vein where the venous catheter is located, associated with a bacteremia. A distinction is made between superficial and deep thrombophlebitis. The frequency of septic thrombophlebitis of venous catheters is variable and poorly described in the literature. When the diagnosis of septic thrombophlebitis is made, it is recommended to extend the duration of antibiotic therapy, to remove the infected catheter and to prescribe anticoagulant treatment. However, there is no recommendation on the duration of anticoagulation for septic thrombophlebitis, whether it is deep or superficial. Investigator proposes a prospective and descriptive interventional study to describe the ultrasound evolution of thrombus in patients with septic thrombophlebitis on central venous catheter and midline.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Adult patient hospitalised at the CHM or CHUA, with a central venous device (Implantable chamber, central venous jugular, femoral, subclavian, PICCline, dialysis catheter) or a Midline and having catheter-related bacteremia

• Catheter-related bacteremia according to the following definition (ePOPI): Positive blood cultures within 48 hours of a suspected catheter infection (or its removal) With one of the following criteria: - Before catheter removal: differential time of positivity of central/peripheral blood cultures ≥ 2 hours

• After catheter removal: positive catheter culture ≥ 103 CFU/ml, with the same organism.

• Patient transportable for ultrasound or ultrasound can be performed in the patient's bed

• Patient capable of giving consent, or consent of the trusted person for patients not capable of giving consent at the time of inclusion

• Written consent signed by the participant and the investigator

• Person affiliated to social security

Locations
Other Locations
France
CHU Angers
NOT_YET_RECRUITING
Angers
Centre Hospitalier Le Mans
RECRUITING
Le Mans
Contact Information
Primary
Christelle JADEAU
cjadeau@ch-lemans.fr
+33244710781
Time Frame
Start Date: 2023-05-31
Estimated Completion Date: 2026-06-30
Participants
Target number of participants: 120
Treatments
Other: Presence of thrombosis
Doppler ultrasound D8, D15, D30, D45, D60 and D90
No_intervention: Absence of thrombosis
Sponsors
Leads: Centre Hospitalier le Mans

This content was sourced from clinicaltrials.gov