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The CCANED-CIPHER Study: Early Cancer Detection and Treatment Response Monitoring Using AI-Based Platelet and Immune Cell Transcriptomic Profiling

Status: Recruiting
Location: See all (4) locations...
Intervention Type: Other, Diagnostic test
Study Type: Observational
SUMMARY

The purpose of the CCANED-CIPHER study is to develop and validate an AI-based blood test for early cancer detection and to monitor treatment effectiveness in cancer patients. This two-phase, multi-center observational study aims to identify specific transcriptomic biomarkers in platelets and immune cells that distinguish cancer patients from healthy individuals and correlate with treatment outcomes. By analysing blood samples using artificial intelligence, the study seeks to create a safe, non-invasive method to enhance cancer diagnosis and monitor treatment responses over time.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Maximum Age: 75
Healthy Volunteers: t
View:

• Age: Adults aged 40 years or older.

• Confirmed diagnosis of one of the following common cancers: Non-Small Cell Lung Cancer (NSCLC), Glioblastoma Multiforme (GBM), Colorectal Cancer, Hepatocellular Carcinoma (HCC), Breast Cancer, Prostate Cancer, Ovarian Cancer, Pancreatic Cancer.

• Adults aged 40 years or older.

• Confirmed diagnosis of: Hepatocellular Carcinoma (HCC), Non-Small Cell Lung Cancer (NSCLC)

• Willingness to provide blood samples at the specified intervals (baseline, 6 weeks, and 6 months post-therapy initiation).

Locations
Other Locations
Argentina
Various Cancer Centres
ACTIVE_NOT_RECRUITING
Rosario
Nigeria
NSIA- Lagos University Teaching Hospital Cancer Centre
RECRUITING
Lagos
United Kingdom
Babraham Research Institute
ENROLLING_BY_INVITATION
Cambridge
Dysplasia Diagnostics Limited
RECRUITING
London
Contact Information
Primary
Javier Toledo, Medical Degree
research@dysplasiadx.com
+44 (0)1223 496000
Backup
Osagie Izuogu, PhD
info@dysplasiadx.com
+44 (0)1223 496000
Time Frame
Start Date: 2025-12-20
Estimated Completion Date: 2028-08-01
Participants
Target number of participants: 6000
Treatments
Cancer Patients (Phase 1)
This arm will include 3,500 individuals with confirmed diagnoses of common cancers such as Non-Small Cell Lung Cancer (NSCLC), Glioblastoma Multiforme (GBM), Colorectal Cancer, Hepatocellular Carcinoma (HCC), Breast Cancer, Prostate Cancer, Ovarian Cancer, and Pancreatic Cancer.
Healthy Individuals
This arm will consist of 1,500 age- and sex-matched cancer-free individuals serving as controls.
Cancer Patients Undergoing Treatment
This cohort will include 1,000 patients diagnosed with Hepatocellular Carcinoma (HCC) or Non-Small Cell Lung Cancer (NSCLC) across stages I to IV who are about to commence standard cancer therapy.
Sponsors
Leads: Javier Toledo

This content was sourced from clinicaltrials.gov