Characterization of High-level Cognitive Impairments in Patients With Neuropsychiatric Disorders

Status: Recruiting
Location: See all (3) locations...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Neuropsychiatric disorders are extremely common, severe, and disabling conditions. In the field of psychiatry, they notably include schizophrenia, mood disorders (depressive and bipolar disorders), autism spectrum or neurodevelopmental disorders, obsessive-compulsive disorder, eating disorders, and personality disorders. In the field of neurology, one can cite neurodegenerative diseases (such as Alzheimer's disease, but also frontotemporal dementia or Parkinson's disease, which often represent frequent and challenging differential diagnoses of psychiatric disorders), focal neurological lesions (notably strokes and tumors), or epilepsy. Cognitive impairments are present in nearly all neuropsychiatric disorders and contribute significantly to disability. While impairments in working memory and attention, executive functions, and social cognition have been relatively well studied, other cognitive domains remain largely unexplored in these populations. This is particularly the case for various aspects of motivation, metacognition, conscious access, or causal (Bayesian) inference. Although these domains likely play an important role in prognosis, no consensus currently exists regarding the methods for evaluating these functions. The main objective of this study is to define a multidimensional, transdiagnostic atlas of high-level cognitive impairments-both specific and shared-across severe psychiatric disorders (notably schizophrenia, depressive disorder, bipolar disorder, autism spectrum or neurodevelopmental disorders, and obsessive-compulsive disorder) and neurological disorders (notably neurodegenerative diseases, focal neurological lesions, and epilepsy), by comparing them to healthy volunteers. The investigators also aim to investigate the progression of cognitive impairments over time, across different phases of illness (symptom stabilization or exacerbation) or therapeutic intervention, through longitudinal follow-up of patients being monitored within the recruiting center. Finally, in a more exploratory manner, the investigators aim to investigate the neural correlates of the identified cognitive impairments.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

⁃ For patients:

• Aged over 18 years

• Diagnosed with a psychiatric disorder according to ICD-10 by a psychiatrist (F10-F98) or diagnosed with a neurological disorder according to ICD-10 by a neurologist (G00-G99)

• Provided written informed consent

• Affiliated with a social security scheme

⁃ For healthy volunteers:

• Aged over 18 years

• Provided written informed consent

• Affiliated with a social security scheme

Locations
Other Locations
France
Departement of Adult Psychiatry, GH Pitié Salpétrière
RECRUITING
Paris
Groupe hospitalo-universitaire Paris Psychiatrie et Neurosciences
RECRUITING
Paris
Hôpital Fondation Adolphe de Rothschild
NOT_YET_RECRUITING
Paris
Contact Information
Primary
Jacob DHOTE, Dr
j.dhote@ghu-paris.fr
+33 145658177
Backup
Fabien VINCKIER, Pr
F.VINCKIER@ghu-paris.fr
Time Frame
Start Date: 2024-03-12
Estimated Completion Date: 2039-03
Participants
Target number of participants: 600
Treatments
Experimental: Cognitive assessment
Neuropsychological assessment assessing different cognitive dimensions (e.g., motivation and decision-making, metacognition, access to consciousness, Bayesian inference)
Sponsors
Leads: Centre Hospitalier St Anne
Collaborators: Institut du Cerveau et de la Moelle (ICM Institute)

This content was sourced from clinicaltrials.gov