Development of an International Multicenter Registry of Patients With Monogenic and Polygenic Autoinflammatory Diseases Aimed at Clinical and Therapeutical Data Collection and Analysis

Status: Recruiting
Location: See all (100) locations...
Intervention Type: Other
Study Type: Observational [Patient Registry]
SUMMARY

Autoinflammatory diseases (AID) are clinical entities characterized by recurrent inflammatory attacks in absence of infection, neoplasm or deregulation of the adaptive immune system. Among them, hereditary periodic syndromes, also known as monogenic AID, represent the prototype of this disease group, caused by mutations in genes involved in the regulation of innate immunity, inflammation and cell death. Based on recent experimental acquisitions in the field of monogenic AID, several immunologic disorders have been reclassified as polygenic/multifactorial AID, sharing pathogenetic and clinical features with hereditary periodic fevers. This has paved the way to new treatment targets for patients suffering from rare diseases of unknown origin, including Behçet's disease, Still disease, Schnitzler's disease, PFAPA (periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis) syndrome, chronic recurrent multifocal osteomyelitis (CRMO), non-infectious uveitis and scleritis. Gathering information on such rare conditions is made difficult by the small number of patients, along with the difficulty of obtaining an accurate diagnosis in non-specialized clinical settings. In this context, the AIDA project promotes international collaboration among clinical centres to develop a permanent registry aimed at collecting demographic, genetic, clinical and therapeutic data of patients affected by monogenic and polygenic AID, in order to expand the current knowledge of these rare conditions.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: No
View:

• to be diagnosed with a monogenic AID according to the clinical phenotype and the detection of a confirmative genotype;

• to be diagnosed with clinical familial Mediterranean fever or Behçet's disease or Still disease or PFAPA syndrome or Schnitzler's disease or CRMO according to the corresponding clinical diagnostic and/or classification criteria;

• to be diagnosed with undifferentiated systemic AID;

• to be diagnosed with non-infectious uveitis according to the standardization for uveitis nomenclature (SUN) criteria;

• to be diagnosed with anterior or posterior non-infectious scleritis.

Locations
United States
Maryland
National Human Genome Research Institute
Not yet recruiting
Bethesda
Other Locations
Algeria
Université M'Hamed Bougara de Boumerdas
Recruiting
Boumerdas
Belgium
Antwerp University Hospital
Recruiting
Antwerp
UZ Leuven Gasthuisberg Campus
Not yet recruiting
Leuven
Brazil
Hospital das Clinicas da Faculdade de Medicina HCFMUSP
Recruiting
São Paulo
Egypt
Cairo University
Recruiting
Cairo
Germany
Charité - Universitätsmedizin Berlin
Not yet recruiting
Berlin
Universitätsklinikum Schleswig-Holstein
Not yet recruiting
Lübeck
Ghana
Korle Bu Teaching Hospital
Not yet recruiting
Accra
Greece
National and Kapodistrian University of Athens
Recruiting
Athens
Islamic Republic of Iran
Shariati Hospital - Tehran University of Medical Sciences
Recruiting
Tehran
Italy
Ospedale San Donato
Not yet recruiting
Arezzo
AOUC Policlinico di Bari
Recruiting
Bari
University-Hospital of Bari - UOC Medicina Interna
Not yet recruiting
Bari
University-Hospital of Bari - UOC Pediatria
Recruiting
Bari
University-Hospital of Bari - UOC Reumatologia
Recruiting
Bari
IRCCS Istituto Ortopedico Rizzoli
Not yet recruiting
Bologna
Central Hospital of Bolzano
Recruiting
Bolzano
ASST degli Spedali Civili
Recruiting
Brescia
ASST degli Spedali Civili - P.O. Ospedale dei Bambini
Recruiting
Brescia
Azienda Ospedaliera Universitaria di Cagliari
Recruiting
Cagliari
AOU Policlinico Vittorio Emanuele - Dip. Materno-Infantile
Not yet recruiting
Catania
Azienda Ospedaliera per l'Emergenza Cannizzaro
Not yet recruiting
Catania
Azienda Ospedaliera di Catanzaro Pugliese Ciaccio
Not yet recruiting
Catanzaro
Ospedale SS Annunziata
Not yet recruiting
Chieti
Arcispedale Sant'Anna
Recruiting
Ferrara
Azienda Ospedaliera Universitaria Careggi - SOD Medicina Interna Interdisciplinare
Recruiting
Firenze
Azienda Ospedaliero-Universitaria Careggi - SOD Immunologia e Terapie Cellulari
Recruiting
Firenze
Azienda Ospedaliero-Universitaria Meyer
Not yet recruiting
Firenze
Azienza Ospedaliero-Universitaria Careggi - SOD Reumatologia
Recruiting
Firenze
Ospedale San Giovanni di Dio
Recruiting
Firenze
Fondazione IRCCS Ospedale Casa Sollievo della Sofferenza
Not yet recruiting
Foggia
IRCCS Ospedale Pediatrico Giannina Gaslini
Not yet recruiting
Genova
ASL1 Avezzano, Sulmona, L'Aquila
Recruiting
L'aquila
Università degli Studi di L'Aquila - UOC Medicina Interna e Nefrologia
Not yet recruiting
L'aquila
Sapienza University - Polo Pontino
Recruiting
Latina
Ospedale Galateo - San Cesario
Not yet recruiting
Lecce
AOU Policlinico G. Martino
Recruiting
Messina
ASST Gaetano Pini/ CTO
Recruiting
Milan
Policlinico di Milano
Recruiting
Milan
ASST Fatebenefratelli Sacco - UO Medicina Generale
Recruiting
Milano
ASST Fatebenefratelli Sacco - UOC Reumatologia
Not yet recruiting
Milano
IRCCS Ospedale San Raffaele
Not yet recruiting
Milano
Ospedale Fatebenefratelli e Oftalmico
Not yet recruiting
Milano
AOU Luigi Vanvitelli - UO Reumatologia
Recruiting
Napoli
AOU Luigi Vanvitelli - UOC Pediatria 2
Not yet recruiting
Napoli
Policlinico Federico II
Not yet recruiting
Napoli
Azienda Ospedaliera Universitaria di Padova
Not yet recruiting
Padova
ARNAS Ospedale Civico di Cristina Benfratelli
Recruiting
Palermo
Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello
Recruiting
Palermo
Università degli Studi di Palermo
Not yet recruiting
Palermo
AOU di Parma - Ospedale dei Bambini P. Barilla
Not yet recruiting
Parma
Fondazione IRCCS Policlinico San Matteo - Dip. Medicina Diagnostica e Servizi: L.S.R. Area Biotecnologie
Not yet recruiting
Pavia
Fondazione IRRCS San Matteo - SC Reumatologia
Recruiting
Pavia
Azienda Ospedaliera di Perugia
Recruiting
Perugia
Azienda USL di Piacenza
Not yet recruiting
Piacenza
Azienda Ospedaliera Universitaria di Pisa
Not yet recruiting
Pisa
Azienda Ospedaliera San Carlo
Not yet recruiting
Potenza
Grande Ospedale Metropolitano - Azienda Ospedaliera Bianchi-Melacrino-Morelli
Not yet recruiting
Reggio Calabria
Arcispedale Santa Maria Nuova
Not yet recruiting
Reggio Emilia
AOU Policlinico Umberto I
Not yet recruiting
Roma
Azienda Ospedaliera San Camillo Forlanini
Recruiting
Roma
IRCCS Fondazione PU Agostino Gemelli - UOC Medicina Interna Columbus
Recruiting
Roma
IRCCS Fondazione PU Agostino Gemelli - UOC Pediatria
Recruiting
Roma
Ospedale Pediatrico Bambino Gesù
Recruiting
Roma
Ospedale Universitario Campus Bio-Medico
Recruiting
Roma
Sapienza University - Polo Pontino - SCIAC
Recruiting
Roma
Azienda Ospedaliera Universitaria di Salerno
Not yet recruiting
Salerno
Azienda Ospedaliero-Universitaria Senese
Recruiting
Siena
ATS Sardegna
Not yet recruiting
Tempio Pausania
AO Ordine Mauriziano
Recruiting
Torino
Presidio Ospedaliero Molinette
Not yet recruiting
Torino
Presidio Ospedaliero Santa Chiara
Not yet recruiting
Trento
Azienda Ospedaliera Universitaria Integrata
Not yet recruiting
Verona
Lebanon
American University of Beirut
Not yet recruiting
Beirut
Morocco
Mohammed V University
Not yet recruiting
Rabat
Poland
Medical University of Lodz
Recruiting
Łódź
Pomeranian Medical University
Not yet recruiting
Szczecin
Central Clinical Hospital of the Ministry of National Defense - Military Institute of Medicine
Recruiting
Warsaw
Portugal
Centro Hospitalar e Universitário do Porto
Not yet recruiting
Porto
Romania
Sf. Maria Hospital - University of Medicine and Pharmacy Carol Davila
Not yet recruiting
Bucharest
Saudi Arabia
King Faisal Specialist Hospital and Research Center
Recruiting
Riyadh
King Saud University
Recruiting
Riyadh
Spain
Hospital Clinic of Barcelona
Recruiting
Barcelona
Vall d'Hbron University Hospital
Not yet recruiting
Barcelona
Hospital Ramón y Cajal
Not yet recruiting
Madrid
Hospital Universitario Marqués de Valdecilla
Recruiting
Santander
Hospital Álvaro Cunquiero-Complejo Hospitalario Universitario de Vigo
Not yet recruiting
Vigo
Taiwan
China Medical University
Not yet recruiting
Taichung
Turkey
Çukurova University
Not yet recruiting
Adana
Ankara University
Not yet recruiting
Ankara
Ankara Yıldırım Beyazıt University
Recruiting
Ankara
Gazi University
Recruiting
Ankara
Antalya Education and Research Hospital
Not yet recruiting
Antalya
Erzurum Education and Research Hospital
Not yet recruiting
Erzurum
Eskişehir Osmangazi University
Not yet recruiting
Eskişehir
Cerrahpasa Medical School Istanbul University
Recruiting
Istanbul
Dokuz Eylul University School of Medicine
Not yet recruiting
İzmir
Manisa Celal Bayar University
Recruiting
Manisa
Sivas Cumhuriyet University
Recruiting
Sivas
Contact Information
Primary
Luca Cantarini, MD,PhD
cantarini@unisi.it
+393479385457
Time Frame
Start Date: August 6, 2020
Estimated Completion Date: August 6, 2030
Participants
Target number of participants: 3500
Treatments
Patients affected by autoinflammatory diseases
Sponsors
Leads: University of Siena

This content was sourced from clinicaltrials.gov

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