Elite in Brain Tumor

Dr. Donald M. O'rourke

Neurosurgery
Penn Medicine
Penn Gamma Knife Center
801 Spruce Street, Spruce Building, 1st Floor, 
Philadelphia, PA 
On Staff At
Accepting New Patients
Elite in Brain Tumor
Penn Medicine
Penn Gamma Knife Center
801 Spruce Street, Spruce Building, 1st Floor, 
Philadelphia, PA 
OverviewInsuranceLocationsClinical ResearchSimilar Doctors

Overview

Donald O'rourke is a Neurosurgery provider in Philadelphia, Pennsylvania. Dr. O'rourke is rated as an Elite provider by MediFind in the treatment of Brain Tumor. His top areas of expertise are Glioblastoma, Astrocytoma, Glioma, Awake Craniotomy, and Gastrostomy. Dr. O'rourke is currently accepting new patients.

His clinical research consists of co-authoring 136 peer reviewed articles and participating in 2 clinical trials. MediFind looks at clinical research from the past 15 years. In particular, he has co-authored 76 articles in the study of Brain Tumor.

Graduate Institution
University Of Pennsylvania School Of Medicine
Residency
Hospital of the University of Pennsylvania
Specialties
Neurosurgery
Licenses
Neurological Surgery in PA
Board Certifications
Neurological Surgery, 1998
Fellowships
Hospital of the University of Pennsylvania
Hospital Affiliations
Hospital Of Univ Of Pennsylvania
Pennsylvania Hospital
Languages Spoken
English
Gender
Male
Awards
Recognized annually in Philadelphia magazine's Top Docs issue from 2005 through 2025

Insurance

Accepted insurance can change. Please verify directly with the provider.

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Accepted insurance plans:

Aetna
  • EPO
  • HMO
  • POS
  • PPO
Cigna
  • EPO
  • HMO
  • PPO
Clover Health
  • INSURANCE PLAN
  • MEDICARE MAPD
Devoted Health
  • MEDICARE MAPD
  • OTHER MEDICARE
Geisinger
  • HMO
  • POS
  • PPO
Highmark
  • EPO
  • HMO
  • PPO
Humana
  • HMO
  • INDEMNITY
  • POS
  • PPO
Independent Health
  • EPO
  • POS
  • PPO
Medicare
  • INSURANCE PLAN
  • MANAGED MEDICAID PLAN
  • MEDICARE MAPD
  • MEDICARE PDP
  • MEDICARE SNP
  • MEDICARE-MEDICAID PLAN
  • OTHER MEDICARE PART D
Oscar
  • EPO
  • HMO
  • PPO
Provider Partners Health Plan
  • MEDICARE SNP
UnitedHealthcare
  • EPO
  • HMO
  • POS
  • PPO
UPMC
  • EPO
  • PPO
View 8 Less Insurance Carriers -

Locations

Penn Gamma Knife Center
801 Spruce Street, Spruce Building, 1st Floor, Philadelphia, PA 19107
Call: 215-662-3487
Other Locations
Penn Neuroscience Center - Neurosurgery
3400 Civic Center Boulevard, South Pavilion, 2nd Floor, Philadelphia, PA 19104

Additional Areas of Focus

Dr. O'rourke has provided the following conditions as areas of focus. Please note that we may not have enough data to validate their experience in some of these conditions.

Ependymoma
Glioblastoma
Oligodendroglioma

Clinical Research

Clinical research consists of overseeing clinical studies of patients undergoing new treatments and therapies, and publishing articles in peer reviewed medical journals. Providers who actively participate in clinical research are generally at the forefront of the fields and aware of the most up-to-date advances in treatments for their patients.

2 Clinical Trials

A Phase 3 Randomized Double-blind, Controlled Study of ICT-107 With Maintenance Temozolomide (TMZ) in Newly Diagnosed Glioblastoma Following Resection and Concomitant TMZ Chemoradiotherapy
A Phase 3 Randomized Double-blind, Controlled Study of ICT-107 With Maintenance Temozolomide (TMZ) in Newly Diagnosed Glioblastoma Following Resection and Concomitant TMZ Chemoradiotherapy
Enrollment Status: Suspended
Publish Date: April 03, 2024
Intervention Type: Biological
Study Phase: Phase 3
Long-term Follow-up of Subjects Exposed to Lentiviral-based CART-EGFRvIII Gene-modified Cellular Therapy Products in Cancer Studies
Long-term Follow-up of Subjects Exposed to Lentiviral-based CART-EGFRvIII Gene-modified Cellular Therapy Products in Cancer Studies
Enrollment Status: Completed
Publish Date: June 22, 2023
View 1 Less Clinical Trial

136 Total Publications

The development of CAR T cells for patients with CNS malignancies.
The development of CAR T cells for patients with CNS malignancies.
Journal: Nature reviews. Clinical oncology
Published: October 30, 2025
View All 136 Publications
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 (2.1 miles away)
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Steven Brem is a Neurosurgery provider in Philadelphia, Pennsylvania. Dr. Brem is rated as an Elite provider by MediFind in the treatment of Brain Tumor. His top areas of expertise are Glioblastoma, Astrocytoma, Glioma, Awake Craniotomy, and Gastrostomy.

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Nduka Amankulor is a Neurosurgery provider in Philadelphia, Pennsylvania. Dr. Amankulor is rated as an Elite provider by MediFind in the treatment of Brain Tumor. His top areas of expertise are Glioma, Astrocytoma, Glioblastoma, Awake Craniotomy, and Gamma Knife Radiosurgery. Dr. Amankulor is currently accepting new patients.

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King Of Prussia, PA 
 (16.1 miles away)
Languages Spoken:
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Kevin Judy is a Neurosurgery provider in King Of Prussia, Pennsylvania. Dr. Judy is rated as an Elite provider by MediFind in the treatment of Brain Tumor. His top areas of expertise are Glioma, Meningioma, Astrocytoma, Awake Craniotomy, and Gamma Knife Radiosurgery. Dr. Judy is currently accepting new patients.

VIEW MORE BRAIN TUMOR DOCTORS

Areas of Expertise

MediFind evaluates expertise by pulling from factors such as number of articles a doctor has published in medical journals, participation in clinical trials, speaking at industry conferences, prescribing and referral patterns, and strength of connections with other experts in their field.

Learn more about MediFind’s expert tiers

Find Dr. O'rourke's expertise for a condition
ConditionClose
  • Elite
  • Astrocytoma
    Dr. O'rourke is
    Elite
    . Learn about Astrocytoma.
    See more Astrocytoma experts
  • Brain Tumor
    Dr. O'rourke is
    Elite
    . Learn about Brain Tumor.
    See more Brain Tumor experts
  • Glioblastoma
    Dr. O'rourke is
    Elite
    . Learn about Glioblastoma.
    See more Glioblastoma experts
  • Glioma
    Dr. O'rourke is
    Elite
    . Learn about Glioma.
    See more Glioma experts
  • Gliomatosis Cerebri
    Dr. O'rourke is
    Elite
    . Learn about Gliomatosis Cerebri.
    See more Gliomatosis Cerebri experts
  • Distinguished
  • Atypical Teratoid Rhabdoid Tumor (ATRT)
    Dr. O'rourke is
    Distinguished
    . Learn about Atypical Teratoid Rhabdoid Tumor (ATRT).
    See more Atypical Teratoid Rhabdoid Tumor (ATRT) experts
  • Embryonal Tumor with Multilayered Rosettes
    Dr. O'rourke is
    Distinguished
    . Learn about Embryonal Tumor with Multilayered Rosettes.
    See more Embryonal Tumor with Multilayered Rosettes experts
  • Ependymoma
    Dr. O'rourke is
    Distinguished
    . Learn about Ependymoma.
    See more Ependymoma experts
  • Gliosarcoma
    Dr. O'rourke is
    Distinguished
    . Learn about Gliosarcoma.
    See more Gliosarcoma experts
  • Hydrocephalus
    Dr. O'rourke is
    Distinguished
    . Learn about Hydrocephalus.
    See more Hydrocephalus experts
  • Metastatic Brain Tumor
    Dr. O'rourke is
    Distinguished
    . Learn about Metastatic Brain Tumor.
    See more Metastatic Brain Tumor experts
View All 11 Distinguished Conditions
  • Advanced
  • Awake Craniotomy
    Dr. O'rourke is
    Advanced
    . Learn about Awake Craniotomy.
    See more Awake Craniotomy experts
  • Brain Abscess
    Dr. O'rourke is
    Advanced
    . Learn about Brain Abscess.
    See more Brain Abscess experts
  • Brain Herniation
    Dr. O'rourke is
    Advanced
    . Learn about Brain Herniation.
    See more Brain Herniation experts
  • Brain Stem Cancer
    Dr. O'rourke is
    Advanced
    . Learn about Brain Stem Cancer.
    See more Brain Stem Cancer experts
  • Chiari Malformation
    Dr. O'rourke is
    Advanced
    . Learn about Chiari Malformation.
    See more Chiari Malformation experts
  • Chiari Malformation Type 1
    Dr. O'rourke is
    Advanced
    . Learn about Chiari Malformation Type 1.
    See more Chiari Malformation Type 1 experts
View All 12 Advanced Conditions
  • Experienced
  • ALK-Positive Non-Small Cell Lung Cancer
    Dr. O'rourke is
    Experienced
    . Learn about ALK-Positive Non-Small Cell Lung Cancer.
    See more ALK-Positive Non-Small Cell Lung Cancer experts
  • Apoplexy
    Dr. O'rourke is
    Experienced
    . Learn about Apoplexy.
    See more Apoplexy experts
  • Cerebellum Agenesis Hydrocephaly
    Dr. O'rourke is
    Experienced
    . Learn about Cerebellum Agenesis Hydrocephaly.
    See more Cerebellum Agenesis Hydrocephaly experts
  • Cerebral Arteriovenous Malformation
    Dr. O'rourke is
    Experienced
    . Learn about Cerebral Arteriovenous Malformation.
    See more Cerebral Arteriovenous Malformation experts
  • Cerebrospinal Fluid Leak
    Dr. O'rourke is
    Experienced
    . Learn about Cerebrospinal Fluid Leak.
    See more Cerebrospinal Fluid Leak experts
  • Cervical Myelopathy
    Dr. O'rourke is
    Experienced
    . Learn about Cervical Myelopathy.
    See more Cervical Myelopathy experts
View All 22 Experienced Conditions
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